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Hexapeptide-11
A small, six-amino-acid peptide studied for supporting skin's own antioxidant defences and for more elastic-feeling skin.
Source
Lab-made peptide, first found in yeast extracts
Used for
Elastic-feeling skin
How it works
Hexapeptide-11 is a short chain of six amino acids, originally identified in yeast extracts and now made in the lab to high purity for use in skincare.
In laboratory research on skin cells, Hexapeptide-11 supported the cells' own protective and antioxidant systems, helping them stand up to oxidative stress. Testing on volunteers' skin also linked it with improved elasticity.
Hexapeptide-11 suits daily use, morning or evening, and pairs naturally with other antioxidant ingredients as part of a routine focused on skin's resilience.
In laboratory research on skin cells, Hexapeptide-11 supported the cells' own protective and antioxidant systems, helping them stand up to oxidative stress. Testing on volunteers' skin also linked it with improved elasticity.
Hexapeptide-11 suits daily use, morning or evening, and pairs naturally with other antioxidant ingredients as part of a routine focused on skin's resilience.
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A short, six-amino-acid peptide, produced synthetically to high purity
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Supported skin cells' own antioxidant defences in laboratory testing
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Linked with more elastic-feeling skin in testing on volunteers
Questions
What is hexapeptide-11?
Hexapeptide-11 is a short peptide made of six amino acids. It was originally found in yeast extracts and is now made in the lab to high purity, which is the form used in skincare. (Sklirou et al., 2015)
What does research show about hexapeptide-11?
In laboratory research on skin cells, hexapeptide-11 switched on the cells' own protein-recycling and antioxidant defences and helped protect them against oxidative stress. The same research found that it improved skin elasticity in tests on volunteers. (Sklirou et al., 2015)
Where it comes from
Hexapeptide-11 was first identified as a natural peptide in yeast extracts. For research and cosmetic use it is now made by synthesis rather than extraction, producing the six-amino-acid chain to high purity. (Sklirou et al., 2015)
The research
- Sklirou AD, Ralli M, Dominguez M, Papassideri I, Skaltsounis AL, Trougakos IP. Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts. Redox Biology. 2015;5:205-215. PMID: 25974626. DOI: 10.1016/j.redox.2015.04.010. (opens in a new tab)
- Wu Y, Cao K, Zhang W, Zhang G, Zhou M. Protective and Anti-Aging Effects of 5 Cosmeceutical Peptide Mixtures on Hydrogen Peroxide-Induced Premature Senescence in Human Skin Fibroblasts. Skin Pharmacology and Physiology, 2021;34(4):194-202 (opens in a new tab)
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